Minoxidil 5%/ Melatonin 0.1% Solution x 60ml (30 day supply)

The science behind minoxidil.

Even if minoxidil has been known for over 30 years as “hair growth stimulator” the precise mechanism of its action is not completely elucitated.

Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase.

Moreover, minoxidil increases hair follicle size. A large part of hair treatment scientific literature confirms the efficacy of topically applied minoxidil in humans. In particular, patients treated with minoxidil showed a significant increase in “non vellus” hair count starting from baseline. Preparation of minoxidil requires molecule stability and solubility.

Today are available on the market minoxidil-based formulations having low-concentration of propylene glycol to obtain preparations with a better cosmetical acceptance and dermatological safety.

The body of evidences indicates that minoxidil still represent a milestone in the treatment of androgenetic alopecia and that its story is going on.

ref – https://pubmed.ncbi.nlm.nih.gov/29319278/

Clinical study on Melatonin helping patients with hair loss issues.

Melatonin, a pleiotropic hormone and affects the physiological processes including that of the hair follicles. A previous clinical study was overlooked to see if melatonin can help individuals suffering from hair loss associated conditions such as Androgenetic type hair loss.

Below is the data posted my PubMed the findings of the clinical study.

“Objective: To summarize the evidence on the association between melatonin and hair health, denoted by hair growth.”

“Methods: A literature review using 3 databases (PubMed, Google Scholar, and Cochrane) identified studies investigating the relationship between melatonin and hair loss (2022). The following search terms were used: (hair OR hair loss OR alopecia OR hair growth OR effluvium OR scalp) and (melatonin). Two independent reviewers screened studies for inclusion criteria, and data collection included demographics, melatonin intervention, study type, and effects on hair.”

“Results: A total of 11 human studies were identified with evidence of melatonin use in subjects with diagnosed alopecia (2,267 patients; 1,140M). Eight of the studies reviewed observed positive outcomes after topical melatonin use in subjects with androgenetic alopecia (AGA). Most studies report improved scalp hair growth (n=8), density (n=4), and hair shaft thickness (n=2) among melatonin users compared with controls. Effective topical melatonin dosage appears to be 0.0033% or 0.1% solution applied once-daily for 90 to 180 days vs 1.5 mg twice-daily oral melatonin supplementation for 180 days.”

“Conclusion: There is evidence to support melatonin use to facilitate scalp hair growth, particularly in men with AGA. Further studies should include more patients and investigate the mechanism of action. J Drugs Dermatol. 2023;22(3): doi:10.36849/JDD.6921.”

ref – https://pubmed.ncbi.nlm.nih.gov/36877877/